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Coronary artery disease (CAD) is also called as coronary heart disease. This is a condition in which plaque builds up inside the arteries which supply oxygen- rich blood to heart muscle. Plaque is made up of substances like fat, cholesterol, calcium, and other substances found in the blood. The formation of plaque in the arteries, is called as atherosclerosis. Plaque narrows the arteries and reduces blood flow to heart muscle. It makes it more likely to form blood clots in arteries which can partially or completely block blood flow. The completely blocked blood flow to the heart muscle can cause heart attack, which can lead to serious problems and even death if quick treatment is not provided. Dilated (Congestive) cardiomyopathy is the most common type of the disease. It mostly occurs in adults aged 20 to 60. The disease often starts in the left ventricle, the main pumping chamber of heart.The heart muscle begins to dilate and due to this the inside of the chamber enlarge. When the chambers dilate, the heart muscle doesnt contract normally. Moreover, the heart cant pump blood very well. Over time, the heart becomes weaker and heart failure can occur. Dilated cardiomyopathy also leads to arrhythmias, heart valve problems, and blood clots in the heart. This type of cardiomyopathy occurs when the muscle mass of the left ventricle enlarges or hypertrophies. Despite this thickening the ventricle size often remains normal.The recent trials supports the theory of paracrine manner rather then stem cells regeneration process by dividing and renewing themselves in to required cells type and can thus replicate and proliferate to form the heart muscle. As per paracrine mechanism stem cells are believed to work by secreting various chemical/ substances that helps in activation of regeneration process. Dilated cardiomyopathy can be the end- stage form and common denominator of several cardiac disorders of known cause such as hypertensive, ischemic, diabetic and Chagasic diseases. Regenerative treatment of dilated, non- ischaemic cardiomyopathy represents a significant unmet clinical need. At Stemcure, we provide services to the institute / Clinics / Clinician / CRO for stem cells development for DCM to conduct clinical trial for following conditions after obtaining regulatory approval.Heart failure or conjuctive cardiac failure is a life threatening condition in which the heart is not able to receive enough blood and oxygen as a result cannot pump enough blood through the body for its routine function. The cause of this can be either thickened or weakened heart muscle, blocked coronary arteries, arrhythmias, damaged heart valves, pericardial disease or uncontrolled hypertension. According to World Health Organization (WHO) estimates, in 2003, number of deaths, including men, women and children due to CVD each year is 16.7 million people around the globe and this is over 29 percent of all deaths globally. By 2020, the number of fatalities projected to increase to more than 20 million a year and to more than 24 million a year by 2030 making heart disease leading cause of death around the world.At Stemcure, we provide services to the institute / Clinics / Clinician / CRO for stem cells development for Heart failure to conduct clinical trial for following conditions after obtaining regulatory approval.,
Keyskills :
coronary artery diseasestem cellsheart valvesheart diseaseheart failureclinical trialcrodcmcvdstembloodsupplyvalvesoxygentrialsmuscleclinicsclinicaldiabetes