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Research Investigator/Scientist- In vitro ADME

7.00 to 12.00 Years   Bangalore   23 Nov, 2021
Sygene
Job LocationBangalore
EducationNot Mentioned
SalaryNot Disclosed
IndustryPharma / Biotech
Functional AreaBio Tech / R&D / Scientist
EmploymentTypeFull-time

Job Description

Designation: Research Investigator/Scientist In vitro ADMEJob Location: BangaloreDepartment: Syngene Amgen Research CenterAbout Syngene:Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.Job Purpose:The incumbent will be responsible for developing and executing in vitro ADMET assays in SARC PKDM.Key Responsibilities:

  • Hands-on experience in developing and implementing fit-for-purpose ADMET assays
  • Experience in Leading group of ADMET scientists including Discovery Bioanalysis
  • In-depth understanding of instrumentation (LCMSMS and UPLC) and have ability to engage in scientific discussion with managers/client while reviewing experimental data.
  • Ability to identify and design studies to delineate druggability issues in the drug discovery programs
  • Expertise in the Bioanalysis and biomarker analysis including developing of robust bioanalytical methods
  • Experience in Biotransformation is a plus
  • Experience in conducting metabolism-based assays and appropriate interpretation of results and participate in client meetings
  • Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
  • Ensuring that there are no safety non-compliances in areas that my team operates in.
  • Ensuring adherence to all Syngene policies related to data integrity by all members of the team including self.
  • Ensuring all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
  • Reporting incidents (or near-misses) and learnings from those incidents to avoid recurrence.
  • Compliance to Syngene s quality standards at all times and ensuring the same by the team members.
Educational Qualification:
  • Ph.D or M.Pharmacy
Technical/functional Skills:
  • Extensive experience and problem-solving ability in Discovery bioanalysis, in vitro ADME assays, biotransformation.
  • In-depth understanding of common in vitro ADME assays, their protocols, sample preparation for Bioanalysis and raw data analysis to arrive at ADME values. Knowledge of biochemical and cell-based assays such as Hepatocyte stability, Caco-2 and MDCK is preferred.
Experience:
  • Ph.D with 2-5 years of experiences or M.Pharmacy with 12 years of experience or M.Sc (Biochemistry or Biotechnology) with 12-14 years of experience.
Behavioral Skills:
  • Good communication skills verbal and written
  • Ability to plan, execute and keep experimental records & prepare protocols as needed
  • Mentor junior scientists
  • Team player
Equal Opportunity Employer:It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.,

Keyskills :
continuous improvement facilitationcgmpdata analysisanimal healthprocess safetyconsumer goodsdata integritydrug discoveryaccountabilityproblem solvingequal employment opportunityprocess developmentin vitroapi

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