seekers for Research Scientist - Invitro ADME - BA

Job Description

Job Title: Research Scientist Invitro ADME - BA Job Location: Bangalore Reporting to: Lead Scientist Job Grade: 7-I About Syngene Syngene ( www.syngeneintl.com ) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit. Mandatory expectation for all roles as per Syngene safety guidelines
• Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene s quality standards at all times.
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time
Core Purpose of the Role: Bioanalytical scientist with expertise in handling, troubleshooting LCMS/MS, LCHRMS/MS, support ADME screening assays bioanalysis, MET ID and understanding of large molecule analysis by LCMS and ability to develop and implement new invitro bioanalytical techniques in line with business needs. Role Accountabilities:
• Delivery of quality data with planning, execution of bioanalytical activities within the team in agreeable timelines
• Mentor a group of scientists for development and implementation of high throughput, fit for purpose bioanalytical methods to support invitro ADME samples analysis
• Identification of problem and trouble shooting in quick turn-around time
• Mentoring team members to generate quality data within agreed timelines
• To perform MET ID studies and providing final quality data with interpretation within agreed timelines
• Peptide/ large molecule bioanalysis
• Coordination with related invitro verticals to plan the bioanalysis in casette
• Excellent written and oral communication skills interacting with internal/external stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
• Adhering to safety and quality policies laid by organization
• Formulation analysis data review and trouble shooting for quicker resolution
• Ensure data compliance as per company procedures.
• Ensuring that there are no safety non-compliances in areas that my team operates in.
• Ensuring adherence to all Syngene policies related to data integrity by all members of the team including self
• Ensuring all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Reporting incidents (or near-misses) and learnings from those incidents to avoid recurrence.
• Compliance to Syngene s quality standards at all times and ensuring the same by the team members.
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time
Syngene Values: All employees will consistently demonstrate alignment with our core values
• Excellence
• Integrity
• Professionalism
Accountabilities as a Syngene Leader:
• Champion effective Environment, Occupational Health, Safety and Sustainability (EHSS) practices for the company and oversee compliance with those practices within Biologics business. Play an active leadership role in monitoring and verifying safety performance through Gemba walks and other safety-led activities.
• Foster a corporate culture that promotes an environment, occupational health, safety, and sustainability (EHSS) mindset as well as the highest standards of quality, integrity, and compliance.
• Put people at the heart of our success by providing clear, active leadership defined by the Syngene leadership framework setting high standards of people management, career planning and talent retention as a priority.
Experience: Minimum 12 to 15 years of relevant industrial experience Technical/functional Skills:
• Expertise in handling & trouble shooting of LCMS/MS and LC-HRMS/MS issues
• Interpretation of data for report preparation and communicating with the relevant stakeholders and the clients
• Hands-on experience in handling of LCMS/MS systems, TOF and/or Orbitrap
• Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction
• Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays. Brief knowledge about Biotransformation of Xenobiotics and basic knowledge on Large molecule analysis using LCMS
• Should be able to deliver the scientific presentation in departmental journal club and write official Project reports
• Should be equipped with quality policies related to data management and data integrity
Behavioral Skills:
• Good communication skills
• Strong problem-solving and handling skills
• Team Player
• Ability to learn/implement new assay in ADME and Analytical
• Quality compliance skills
Educational Qualification:
• M. Pharm in Pharmaceutical sciences
• Relevant master s degree in Pharmaceutical Chemistry or instrumentation.
Equal Opportunity Employer: It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.,

Keyskills :
solid phase extractionapivalidationresearchhplcin vitro