BBRC-Associate Scientist- PCO - In Vitro ADME

Job Description

Designation: Associate Scientist/ Senior Associate Scientist: In Vitro ADME Job Location: Bangalore Department: Pharmaceutical Candidate Optimization- Drug Metabolism and Transporters About Syngene Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.Job Purpose: This is a lab-based position, working with drug metabolism and transporter team. The major purpose will be performing in vitro mechanistic studies (CYP TDI, Ki-Kinact, CYP Induction, CYP and UGT reaction phenotyping) to understand drug-drug interaction potential of new chemical entities and assist the team to deliver on its objectives.Key Responsibilities: The ideal candidate should be experienced in performing In-vitro ADME assays like Metabolic stability, Plasma and blood stability, cytochrome P450 inhibition, plasma protein binding and blood to plasma ratio studies. He/She must have experience in handling of cellular and subcellular fractions such as Microsomes, Hepatocytes, S9 and Cytosol. The candidate must have good data analysis skills and written and oral communication skills. This role requires the candidate to take up some general lab related responsibilities like chemical inventory, instrument monitoring, managing lab safety. Hands on experience with automation (liquid handling systems) would be an added advantage.Educational Qualification and Experience: M.Pharm/M.Sc. with minimum 3-5 years in in-vitro DMPK.Technical/functional Skills: Must have:
• Preparation of compound stocks, buffers, media and other materials required for In-vitro ADME experimental work.
• Perform In-vitro ADME assays like Metabolic stability, Plasma and blood stability, cytochrome P450 inhibition, plasma protein binding and blood to plasma ratio studies
• Handling of cellular and subcellular fractions such as Microsomes, Hepatocytes, S9 and Cytosol etc.
• Hands on experience in other common in vitro ADME assays is highly preferred
• Use of analytical equipment such as HPLC and (u)HPLC-MS/MS will be an added advantage
• Monitoring of consumables stock levels in the laboratory and re-stocking shelves.
• Contributing to process improvement and the sharing of new ideas within the team
• Minimum of 3-5 years of experience in relevant field
Good to have:
• Trouble shooting ability, Good communication Skills-both written and Verbal
• Good interpersonal skills and the ability to work well with other people
• Good organizational and time management skills
• Reliable and Self-motivated.
Equal Opportunity Employer: It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.,

Keyskills :
sopprotocolsmusic makingvalidationhplcdata analysisdocumentation