hireejobs
Register for Job
Hyderabad Jobs
Banglore Jobs
Chennai Jobs
Delhi Jobs
Ahmedabad Jobs
Mumbai Jobs
Pune Jobs
Vijayawada Jobs
Gurgaon Jobs
Noida Jobs
Oil & Gas Jobs
Banking Jobs
Construction Jobs
Top Management Jobs
IT - Software Jobs
Medical Healthcare Jobs
Purchase / Logistics Jobs
Sales
Ajax Jobs
Designing Jobs
ASP .NET Jobs
Java Jobs
MySQL Jobs
Sap hr Jobs
Software Testing Jobs
Html Jobs
IT Jobs
Logistics Jobs
Customer Service Jobs
Airport Jobs
Banking Jobs
Driver Jobs
Part Time Jobs
Civil Engineering Jobs
Accountant Jobs
Safety Officer Jobs
Nursing Jobs
Civil Engineering Jobs
Hospitality Jobs
Part Time Jobs
Security Jobs
Finance Jobs
Marketing Jobs
Shipping Jobs
Real Estate Jobs
Telecom Jobs

Research Investigator

0.00 to 3.00 Years   Delhi   19 May, 2023
Sygene
Job LocationDelhi
EducationNot Mentioned
SalaryNot Disclosed
IndustryPharma / Biotech
Functional AreaBio Tech / R&D / Scientist
EmploymentTypeFull-time

Job Description

    Research Investigator, Chemical Development To support lab scale automated oligonucleotide production and purification at Syngene.
    • Process development for oligonucleotide API/drug substance.
    • Independently handling automated oligo synthesis using solid phase eg. OP100, Mermade etc. and take responsibility to trouble shoot in case of challenges.
    • Tech transfer from lab to plant using sound process engineering principles of oligonucleotides, phosphoramidites, nucleic acid synthesis.
    • Optimization and scale up of oligonucleotide/peptide API (Solid phase synthesis) processing method from Lab scale to manufacturing scale.
    • Interpretation of HPLC/LCMS analysis of oligonucleotides and peptides (ESI, MALDI-TOF, Orbitrap, APCI, Q-TOF, MS/MS etc.)
    • Process engineering troubleshooting, data interpretation using advance software for oligonucleotides and peptides.
    • Regulatory knowledge (US FDA, European FDA etc.) for the development of oligonucleotides.
    • Focus on deliverable of project right from Initiation to end. Evaluate RFPs technically and work with BD to provide proposals to new and existing clients.
    • Lead and manage a team of 2-4 persons to develop new process for oligonucleotides.
    • Manage and develop team through scientific learning and development for oligonucleotides.
    • Communicate seamlessly with the client and provide them the necessary data, take inputs and drive the project to ensure customer satisfaction.
    • Ability to work with leadership and management team.
    Education and Experience Education PhD with postdoctoral experience Industry Experience 0-3 years of relevant experience Other competencies required for the role
    • Having sound knowledge and hands on experience in protecting/deprotecting group chemistry of nucleosides/nucleotides, phosphoramidites, oligonucleotides etc.
    • Sound knowledge of oligonucleotide/peptide synthesis eg. amidite coupling, detritylation, oxidation, thiolation etc. using solid phase/solution phase synthesis.
    • Sound knowledge of cleavage and deprotection conditions, purification, lyophilization etc. for oligonucleotides/peptides.
    • Strong experience in working with wide ranging oligo reagents eg. activators, deblocking agents, thiolating/oxidizing reagents, capping reagents, solid support resins etc.
    • Good exposure to various oligonucleotides such as siRNA, antisense, miRNA, aptamers, branching oligonucleotides, oligonucleotide-conjugates eg. GalNac, Vit.E, cholesterol or peptides.
    • Good working knowledge and experience in handling preparative or buffer based HPLC/LPLC.
    • Adequate knowledge of analytical techniques like HPLC, UPLC, GPC etc. for oligonucleotide/peptide applications.
    • Good organizational skills and hands on experience.
    • Excellent in computational skills using various software eg.Unicorn, for synthetic oligonucleotides.
    • In-depth knowledge of cGMP or cGXP in oligonucleotides/peptides synthesis.
    • Ability to work in an industrial set-up involving cross-functional teams from QC, QA, production etc. in synthetic large molecule area.
    • Excellent technical writing and documentation skills.
    • Excellent communication skills and capable of interacting with multiple clients.
    ,

Keyskills :
data managementprocess developmentcgmp

APPLY NOW

Research Investigator Related Jobs

© 2019 Hireejobs All Rights Reserved