Senior Research Associate - Invitro ADME-BA

Job Description

Job Title: Senior Research Associate Invitro ADME-BA Job Location: Bangalore Reporting to: Principal Scientist Job Grade: 9-II About Syngene : Syngene ( www.syngeneintl.com ) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit. Mandatory expectation for all roles as per Syngene safety guidelines
• Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene s quality standards at all times.
Core Purpose of the Role: Bioanalytical scientist with expertise in handling LCMS/MS and support ADME screening assays: InVitro assays, MET ID and large molecule analysis by LCMS and in line with business needs. Ro le Accountabilities:
• Optimization of test compounds and to develop high throughput, fit for purpose LC-MS/MS and HPLC-UV methods to support ADME samples analysis: Formulations analysis, solubility studies, stability studies, In vitro assays, MET ID and large molecule analysis etc.
• Perform analysis of samples generated for the screening of compounds for ADME assays and Processing of different matrices/formulation samples of PK studies
• Excellent written and oral communication skills interacting with internal stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, scheduling calibration and maintaining documentation as per regulatory compliance and company policy
• Adhering to safety and quality policies laid by organization
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene s data integrity policies
• Compliance to Syngene s quality standards at all times.
Syngene Values: All employees will consistently demonstrate alignment with our core values
• Excellence
• Integrity
• Professionalism
Experience: Minimum 0 to 3 years of relevant industrial experience Technical / functional Skills:
• Hands-on experience in handling of HPLC-UV systems is mandatory and experience on LC-MS/MS is advantageous
• Fair knowledge in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction
• Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays.
• Should assist/ deliver the scientific presentation in departmental journal club and write official Project reports
• Should be equipped with quality policies related to data management and data integrity
Behavioral Skills:
• Good communication skills
• Strong problem-solving and handling skills
• Team Player
• Ability to learn/implement new assay in ADME and Analytical
• Quality compliance skills
Educational Qualification:
• M. Pharm in Pharmaceutical sciences
• Relevant master s degree in Pharmaceutical Chemistry or instrumentation.
Equal Opportunity Employer: It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.,

Keyskills :
literaturesolid phase extractiondata managementproblem solvingnmrhplcvalidationresearch