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Associate Scientist- Invitro ADME Bioanalyst

5.00 to 8.00 Years   Kolkata   26 Feb, 2021
Syngene International Limited
Job LocationKolkata
EducationNot Mentioned
SalaryNot Disclosed
IndustryEducation / Training
Functional AreaBio Tech / R&D / Scientist
EmploymentTypeFull-time

Job Description

Designation: Associate ScientistJob Location: BangaloreDepartment: Discovery BiologyAbout SyngeneIncorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.Job Purpose: To handle LCMS/MS, support ADME screening assays, MET ID and understanding of large molecule analysis by LCMS in line with business needs.Key Responsibilities:

  • Optimization of test compounds and to develop high throughput, fit for purpose methods to support invitro ADME samples analysis
  • Perform analysis of samples generated for the screening of compounds for ADME assays and Processing of different matrices samples of PK studies
  • To support MET ID studies and peptide/ large molecule bioanalysis
  • Excellent written and oral communication skills interacting with internal stakeholders
  • Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
  • Preparation of protocols, reports and templates for responsibilities
  • Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
  • Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
  • Attend training on environment, health, and safety (EHS) measures imparted by company.
Educational Qualification:
  • M. Pharm in Pharmaceutical sciences
  • Relevant master s degree in Pharmaceutical Chemistry or instrumentation.
Technical / functional Skills:
  • Hands-on experience in handling of LCMS/MS systems is mandatory and experience on TOF/Orbitrap is advantageous
  • Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory
  • Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays. Brief knowledge about Biotransformation of Xenobiotics and basic knowledge on Large molecule analysis using LCMS
  • Should be able to deliver the scientific presentation in departmental journal club and write official Project reports
  • Should be equipped with quality policies related to data management and data integrity
Experience:Minimum 5 to 8 years of relevant industrial experienceBehavioral Skills:
  • Good communication skills
  • Strong problem-solving and handling skills
  • Team Player
  • Ability to learn/implement new assay in ADME and Analytical
  • Quality compliance skills
Equal Opportunity Employer:It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.,

Keyskills :
continuous improvement facilitationsolid phase extractionin vitroprotocolsanimal healthhplcvalidationdata managementsopequal employment opportunityproblem solvingdocumentationconsumer goods

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