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Research Associate-Oligonucleotide R&D

1.00 to 4.00 Years   Kolkata   26 Apr, 2021
Job LocationKolkata
EducationNot Mentioned
SalaryNot Disclosed
IndustryPharma / Biotech
Functional AreaBio Tech / R&D / Scientist
EmploymentTypeFull-time

Job Description

Designation: Research Associate, Chemical DevelopmentJob Location: Bengaluru, IndiaReporting to: Lead Investigator, OligonucleotidesJob Grade: 9Operating Unit : Chemical DevelopmentDepartment: Oligonucleotides R&DThe CompanySyngene International Ltd. (BSE: 539268, NSE: SYNGENE, ISIN: INE398R01022), is an integrated research, development and manufacturing services company serving the global pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical sectors. Syngene s 4500+ scientists offer both skills and the capacity to deliver great science, robust data management and IP security and quality manufacturing, at speed, to improve time-to-market and lower the cost of innovation. With a combination of dedicated research facilities for Amgen, Baxter, Bristol-Myers Squibb and Herbalife, as well as 1.9 Mn sq ft of specialist discovery, development and manufacturing facilities, Syngene works with biotech companies pursuing leading edge science as well as multinationals including GSK and Merck KGaA.The Role To support lab scale automated oligonucleotide production and purification at Syngene.Key Result AreasRole-specific:

  • The candidate is expected to help in process development in the laboratory and provide technical inputs and hands on support to ongoing projects, based on thorough literature information or evaluation of available experimental data.
  • Knowledge of chemical reaction optimization and experience in anion exchange chromatography and ultrafiltration is essential. Having previous oligonucleotide/peptide synthesis experience is desirable.
  • Design and execute the automated solid-phase oligonucleotide synthesis and purification at small to mid-scale.
  • Method development for improved oligonucleotide synthesis and purifications, that can be translated to pilot scale production.
  • Operate, maintain & troubleshoot oligonucleotide synthesis instruments, purification instruments and other scientific equipment.
  • Supporting process engineers/production personal for the development of the processes feasible to execute at the manufacturing facility.
  • Ability to develop a deep knowledge about oligonucleotide synthetic chemistry and probable troubleshooting. The candidate must have flexibility to learn new chemistry and techniques related to oligonucleotide synthesis.
  • Transfer of chromatography and ultrafiltration processes from small scale to the large scale.
  • Possess the knowledge and exposure to environment, health, and safety (EHS) practices
  • Ensure environment, health, and safety (EHS) measures are always training and adhered within the team
Education and Experience EducationMaster s degree in Chemistry Industry Experience 0-3 years of relevant experienceOther competencies required for the role
  • Experience in working in a Biological/Peptide/Oligonucleotides upstream/downstream laboratory.
  • Experience in setting up experiments and generate data suitable for technology transfer and execution at large scale.
  • Good understanding of synthetic organic chemistry and solid phase synthesis.
  • Experience in Akta system and Unicorn software is essential.
  • Should be able to understand software interface for the various requirements in oligo synthesizer, Ultrafiltration or Chromatography.
  • Should have the capability to work in a team and ability to handle demonstrate a good team spirit.
  • While possessing a good ability to follow instruction should also demonstrate innovative in his/her approach, good communication skills.
  • Should be proactive while working on allotted responsibility
Equal Opportunity EmployerIt is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.Please visit us at https://syngeneintl.com/ to know more about us and what we do. ,

Keyskills :
data managementprocess developmenthplcoptimization strategiesdocumentationorganic chemistrycalibrationtechnology transferlegislative relationsresearchvalidationconsumer goods

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