Research Associate - Upstream Process Development

Job Description

Job Title: Research Associate Job Location: Bengaluru, India Reporting to: Senior Research Scientist Job Grade: 9-IAbout Syngene: Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spiritMandatory expectation for all roles as per Syngene safety guidelines Overall adherence to safe practices and procedures of oneself and the teams aligned Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company s integrity & quality standards Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times. Ensuring safety of self, teams, and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace. Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self Compliance to Syngene s quality standards at all times Hold self and their teams accountable for the achievement of safety goals Govern and Review safety metrics from time to timeCore Purpose of the role: The incumbent will be responsible for execution at bench [~100% time] for cell culture / fermentation development and process transfer in support of in-process early-stage biopharmaceutical development programs - and will work with crosss functional departments.Role Accountabilities: Primary responsibility for all aspects of mammalian/microbial cell culture, including media and buffer preparation, culture initiation, propagation, and cryopreservation of cells while adhering to quality systems. Performance of basic laboratory protocol studies, including basic calculations and data recording. Media/Feed/Additives preparation in both mammalian and microbial fermentation. Performing mammalian/microbial cell culture process development experiments in shake flasks, and bioreactors. Recording data contemporaneously, posting in the respective excel sheets and plotting graphs. Handling 10L/50L bioreactors and Ambr 250 bioreactors. Analysing in-process culture samples using Vi-Cell, BGA, Osmo and Nova, UV. Performance of general laboratory tasks like maintenance of equipment, calibration and PM. Follow Standard Operating Procedures and adhere to all safety and company policies. To perform in-process testing during experiment. Should be able to troubleshoot in case of any deviation from process/parameter. Assess/investigate the reason for process/equipment failure. Evaluation of incoming technical documents for process understanding. Preparation of documents required for execution and technology transfer. Review and interpretation of data received from analytical functions. To co-ordinate with analytical and other functions on planning of experiments and intimation of samples and tests to be performed. Maintain the laboratory with all necessary requirements and track the inventory to ensure minimum stock is maintained. Based on business requirement job role has all shifts including night shift. To carry out other responsibilities that may be assigned by the Superior.Syngene ValuesAll employees will consistently demonstrate alignment with our core values Excellence Integrity ProfessionalismEducational Qualification: Bachelor s/Master s degree in Life SciencesSkills and Capabilities: Performance of basic laboratory protocol studies, including basic calculations and data analysis. Accurate and reliable record keeping including database management, batch records, notebooks, and all pertinent documentation. Sterile preparation of laboratory glassware, tools, and reagents. Performance of general laboratory tasks, including maintenance of equipment. Follow Standard Operating Procedures and adhere to all safety and company policies. To perform in-process testing during experiment. Should be able to troubleshoot in case of any deviation from process/parameter. Assess/investigate the reason for process/equipment failure.Experience: 0-3 years of experience,

Keyskills :
standard operating proceduresdocumentationcalibrationdata integrityhplcvalidation