Research Investigator

Job Description

Designation: Research Investigator, Chemical Development Job Location: Bengaluru, India Reporting to: Lead Investigator, Oligonucleotides Job Grade: 7 Operating Unit : Chemical Development Department: Oligonucleotides R&D The Company Syngene International Ltd. (BSE: 539268, NSE: SYNGENE, ISIN: INE398R01022), is an integrated research, development and manufacturing services company serving the global pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical sectors. Syngene s 4500+ scientists offer both skills and the capacity to deliver great science, robust data management and IP security and quality manufacturing, at speed, to improve time-to-market and lower the cost of innovation. With a combination of dedicated research facilities for Amgen, Baxter, Bristol-Myers Squibb and Herbalife, as well as 1.9 Mn sq ft of specialist discovery, development and manufacturing facilities, Syngene works with biotech companies pursuing leading edge science as well as multinationals including GSK and Merck KGaA. The Role To support lab scale automated oligonucleotide production and purification at Syngene. Key Result Areas Role-specific:
• Process development for oligonucleotide API/drug substance.
• Independently handling automated oligo synthesis using solid phase eg. OP100, Mermade etc. and take responsibility to trouble shoot in case of challenges.
• Tech transfer from lab to plant using sound process engineering principles of oligonucleotides, phosphoramidites, nucleic acid synthesis.
• Optimization and scale up of oligonucleotide/peptide API (Solid phase synthesis) processing method from Lab scale to manufacturing scale.
• Interpretation of HPLC/LCMS analysis of oligonucleotides and peptides (ESI, MALDI-TOF, Orbitrap, APCI, Q-TOF, MS/MS etc.)
• Process engineering troubleshooting, data interpretation using advance software for oligonucleotides and peptides.
• Regulatory knowledge (US FDA, European FDA etc.) for the development of oligonucleotides.
• Focus on deliverable of project right from Initiation to end. Evaluate RFPs technically and work with BD to provide proposals to new and existing clients.
• Lead and manage a team of 2-4 persons to develop new process for oligonucleotides.
• Manage and develop team through scientific learning and development for oligonucleotides.
• Communicate seamlessly with the client and provide them the necessary data, take inputs and drive the project to ensure customer satisfaction.
• Ability to work with leadership and management team.
Education and Experience Education PhD with postdoctoral experience Industry Experience 0-3 years of relevant experience Other competencies required for the role
• Having sound knowledge and hands on experience in protecting/deprotecting group chemistry of nucleosides/nucleotides, phosphoramidites, oligonucleotides etc.
• Sound knowledge of oligonucleotide/peptide synthesis eg. amidite coupling, detritylation, oxidation, thiolation etc. using solid phase/solution phase synthesis.
• Sound knowledge of cleavage and deprotection conditions, purification, lyophilization etc. for oligonucleotides/peptides.
• Strong experience in working with wide ranging oligo reagents eg. activators, deblocking agents, thiolating/oxidizing reagents, capping reagents, solid support resins etc.
• Good exposure to various oligonucleotides such as siRNA, antisense, miRNA, aptamers, branching oligonucleotides, oligonucleotide-conjugates eg. GalNac, Vit.E, cholesterol or peptides.
• Good working knowledge and experience in handling preparative or buffer based HPLC/LPLC.
• Adequate knowledge of analytical techniques like HPLC, UPLC, GPC etc. for oligonucleotide/peptide applications.
• Good organizational skills and hands on experience.
• Excellent in computational skills using various software eg.Unicorn, for synthetic oligonucleotides.
• In-depth knowledge of cGMP or cGXP in oligonucleotides/peptides synthesis.
• Ability to work in an industrial set-up involving cross-functional teams from QC, QA, production etc. in synthetic large molecule area.
• Excellent technical writing and documentation skills.
• Excellent communication skills and capable of interacting with multiple clients.
Equal Opportunity Employer It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities. Please visit us at https://syngeneintl.com/ to know more about us and what we do.,

Keyskills :
scale uplegislative relationsaccountabilityequal employment opportunityprocess engineeringcgmpdata interpretationanalytical techniquesapiprocess developmenttechnical writingdata management